When activated, mast cells release inflammatory mediators causing episodic multi-organ symptoms such as hives, swelling, flushing, nausea, vomiting, diarrhea, abdominal pain, low blood pressure, fainting, heart palpitations, wheezing, red eyes, itching, and/or nasal congestion. Studies showed that mast cells play a significant role in a host of inflammatory, infectious, and functional disorders of the lungs, eyes, skin, joints, and gastrointestinal tract. Mast cells also participate in the development of autoimmune disorders and postural orthostatic tachycardia syndrome (POTS).
MCAS can be triggered by medications, foods, supplements, hormones, opioids, stressors, cold or heat, pressure, noxious odors, chemicals, insect bites, trauma or biotoxins, such as mold, inflammagens, and lyme-related toxins seen in CIRS.
Mast cell stabilization through histamine and tryptase inhibition is a mechanism to consider in providing support for patients suffering from mast cell activation syndrome (MCAS).