Urolithin A is the main metabolite of ellagitannin rich foods, such as pomegranates, black raspberries, raspberries, strawberries, walnuts and almonds. These polyphenol components are not absorbed intact into the bloodstream, but are hydrolyzed to ellagic acid in the gut, which is then metabolized by the gut microflora to form urolithin A and B.
Research indicates that the ability to synthesize urolithins declines with age and depends on the gut microflora, and there is a small percentage of the population that is unable to perform this conversion at all. Research indicates that urolithin A enhances autophagy, the natural process of cellular renewal in which the body degrades and recycles cellular components, as well as mitophagy, the clearance and recycling of older and dysfunctional mitochondria.
Mitochondria are the “powerhouses of the cell” and their function is fundamental to healthy aging. Efficient rejuvenation of mitochondria supports energy production and the overall health of cells. . In animal research, urolithin A enhanced mitophagy to promote mitochondrial biogenesis and function during aging.4It also improved endurance and exercise capacity in both young and age-related models of muscle decline. Supporting autophagy reduces oxidative stress and promotes healthy cytokine balance within the cells to support healthy aging.
These results are believed to be the result of increased expression of genes targeting fatty acid beta oxidation, adipose tissue lipolysis and insulin receptor function (Sirt1), and oxidation defenses(SOD1 and SOD2). Sirt1 is also a target of resveratrol thereby offering support for longevity, metabolic health, and mitochondrial function.10,11 CoQ10 is a key nutrient used in the energy production pathway.
Suggested use: As a dietary supplement, take 2 capsules, 1-2 times daily, with or between meals.